The man was rushed to Saints Mary and Elizabeth Medical Center, where he was pronounced dead, police said. He has been identified as Gyovanny Arzuaga.
The woman was struck in the neck and rushed to Stroger Hospital in critical condition, police said.
At least five evidence markers could be seen in the street next to a black SUV. Neighbors peered down a usually busy Division Street to get a look at the investigation, some even stopping to ask what happened.
Area Four detectives are investigating.